Ferroptosis and endoplasmic reticulum stress
نویسندگان
چکیده
منابع مشابه
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
Exchange of extracellular cystine for intracellular glutamate by the antiporter system xc (-) is implicated in numerous pathologies. Pharmacological agents that inhibit system xc (-) activity with high potency have long been sought, but have remained elusive. In this study, we report that the small molecule erastin is a potent, selective inhibitor of system xc (-). RNA sequencing revealed that ...
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ژورنال
عنوان ژورنال: SCIENTIA SINICA Vitae
سال: 2020
ISSN: 1674-7232
DOI: 10.1360/ssv-2020-0116